ANTIHYPERGLYCEMIC AND ANTIHYPERLIPIDEMIC EFFECTS OF STEPHANIA JAPONICA (THUNB.) MIERS. TENRIL IN ALLOXAN INDUCED DIABETIC MICEAbstract
The present study was carried out to investigate the antihyperglycemic, oral glucose tolerance test (OGTT) and antihyperlipidemic (Total cholesterol and triglycerides) effects of the methanolic extract of Stephania japonica (Thunb.) Miers. tenril (MSJT). The MSJT was administered orally as a dose of 250 and 500 mg/kg body weight to alloxan induced hyperglycemic rats and found to reduce blood glucose level significantly (p<0.05). The MSJT also significantly reduce the lipid content which was increased in hyperglycemic rats. The effects of plant extract were compared with standard drug metformin. The phytochemical screening tests indicated that the different constituents such as saponins, tannins, triterpines, alkaloids, flavonoids and glycosides etc. were present in the plant which has antidiabetic and hypolipidemic properties. Thus, this investigation paves the way for plant based antihyperglycemic and antihyperlipidemic treatment and indicates that MSJL have favorable effect in bringing down the severity of hyperglycemia, enhancing antihyperlipidemic activity and also improving glucose tolerance activity.
M. Chand Sultana , M. Badrul Alam*, M. Asadujjaman and M. Ahsan Akter
Lecturer, Department of Pharmacy, Atish Dipankar University of Science & Technology, Dhaka, Bangladesh
07 April, 2012
14 May, 2012
29 July, 2012
01 August, 2012