ANTIHYPERLIPIDEMIC ACTIVITY OF GLORIOSASUPERBAAbstract
In this study, acute Poloxamer (P-407) and chronic cholesterol and cholic suspension (CCS) models were used in rats to evaluate the antihyperlipidemic potential of methanolic extract of Gloriosasuperba(MEGS). Two different doses of 200 mg/kg and 400 mg/kg were used in acute model.Acute model was used to confirm the prophylactic antihyperlipidemic properties of extract, and further most effective dose obtained was used in chronic model. Solution of P-407 was administered into rats after 8 days of treatment with extract via i.p. (intra-peritoneal) route. In chronic model the hyperlipidemia was induced prior to treatment for 28 days with most effective dose obtained from acute model. Blood was withdrawn from retro-orbital plexus and serum lipid profile levels were estimated from both the models. In chronic model, assay of liver enzymes were estimated after scarification of rats. 400mg/kg showed the most prominent effects from acute model. MEGS reduced 51.56% of total cholesterol (TC), and 98.05% reduction of LDL level were observed in chronic model. Reduced atherogenic index was also observed.
Pal Chandrashekhar R. *, GargeVaibhavi N. and KadamVilasrao J.
Department of Pharmacology, Bharatividyapeeth’s college of Pharmacy, Navi Mumbai Maharashtra, India
22 April, 2015
03 June, 2015
28 August, 2015
01 November, 2015