ANTIHYPERTENSIVE EFFECT OF THE ALCOHOLIC EXTRACT OF SEEDS OF PHASEOLUS VULGARIS LINN. (FABACEAE) ON HIGH SALT DIET INDUCED HYPERTENSION IN MALE RATSAbstract
Aim: To evaluate the antihypertensive effect of ethanolic extract of seeds of Phaseolus vulgaris Linn. (EEPV) on high salt diet induced hypertension in male rats. Methods: Male wistar rats (180-200g) received high salt diet (8% NaCl) and 1% saline water for 6 weeks, then cannulated for dosing of Enalapril, angiotensin converting enzyme inhibitor (0.5 mg/kg, i.v.) in standard group and EEPV (50 and 100 mg/kg, i.v.) in test group and measured mean blood pressure, systolic blood pressure, diastolic blood pressure and heart rate with the help of Power Lab 6 Pro after 60 minutes of treatment. Results: Elevated blood pressure of the animals was significantly (P < 0.05) decreased by EEPV (100 mg/kg, i.v). Enalapril, at the dose of 0.5 mg/kg, i.v. showed significant (P < 0.05) reduction in the elevated blood pressure. The antihypertensive activity of ethanolic extract of seeds of Phaseolus vulgaris Linn. may be due to the action on rennin-angiotensin system. The antihypertensive activity of EEPV might also be explained by the presence of phytochemical constituents like flavanoids and saponins in the plant. Conclusion: The work demonstrated that the concomitant administration of high-salt and EEPV elicits prevention of high salt-induced hypertension in rats. Overall, results justify and support the use of Phaseolus vulgaris Linn. as antihypertensive medicine.
T. Jawaid *, M. Kamal and S. Kumar
Department of Pharmacology, College of Medicine, Dar Al Uloom University, Al Mizan St, Al Falah, Riyadh, Kingdom of Saudi Arabia.
09 December, 2016
08 February, 2017
17 February, 2017
01 July, 2017