ANTIHYPERTENSIVE EFFICACY OF ROUWOLFIA TETRAPHYLLA – ROOT OF THE PLANT ON UNINEPHRECTOMIZED DOCA – SALT HYPERTENSIVE RATSAbstract
The plant Rouwolfia tetraphylla has been used traditionally as antihypertensive and has been proven scientifically to possess high antioxidant and hepato-protective activity. This study was designed to check the potential of medicinal plants in treatment of hypertension which will be helpful to reduce the side and adverse effect of allopathic antihypertensive drugs. During the experimental period, 1% sodium chloride solution was administered orally with drinking water for four weeks and DOCA – salt (20 mg/kg body weight) was injected subcutaneously to elevate the systolic, diastolic and mean arterial blood pressure. The rats were then treated with the methanolic extract of Rouwolfia tetraphylla and a significant decrease in the systolic pressure was recorded. Biochemical assays including serum urea, serum creatinine, triglycerides, cholesterol, blood glucose and serum protein were also performed to assist the hypothesis. The study thus, concludes the anti-hypertensive activity of Rouwolfia tetraphylla in the DOCA – salt hypertensive wister rats.
R. Gadhvi ⃰ , M. N. Reddy and M. Nivserkar
Department of Biotechnology, Shree Bapalal Vaidhya Botanical Research Center, Veer Narmad South Gujarat University, Surat, Gujarat, India.
15 June, 2017
19 September, 2017
26 January, 2018
01 March, 2018