ANTIMICROBIAL AND ANTI-INFLAMMATORY POTENTIAL OF THE LEAF EXTRACTS, COLUMN FRACTIONS AND COMPOUNDS OF THE MEDICINAL PLANT JASMINUM FLEXILE VAHLAbstract
The medicinal plant Jasminum flexile is reported in traditional medicine as an antidiabetic and anti-inflammatory agent. There is no scientific report on the antibacterial and anti-inflammatory activity of extracts of Jasminum flexile. This study investigated the antibacterial and anti-inflammatory potential of the hydroethanol extract of leaves of Jasminum flexile, its column fractions and constituent compounds. The column fractions MF14, MF9 and MF5 expressed a zone of inhibition of 12 mm against Streptococcus mutans and the isolated compound JFLC1 showed a zone of inhibition of 10 mm against Streptococcus mutans, Escherichia coli, and Klebsiella pneumoniae comparable to that of the standards ampicillin, kanamycin and chloramphenicol respectively at the same concentration. The highest anti- inflammatory potential was found for the column fraction MF3 (55.14%) as assessed from the percentage of haemolysis. The results reveal that the isolated compounds and extracts of leaves of Jasminum flexile possess significant antimicrobial and anti-inflammatory potential.
P. Rajasri Bharathi * and Shubashini K. Sripathi
Department of Chemistry, School of Physical Sciences and Computational Sciences, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore, Tamil Nadu, India.
28 April 2022
24 May 2022
25 May 2022
01 June 2022