ANTIMICROBIAL AND ANTIFUNGAL EVALUATION OF NEWLY SYNTHESIZED OXADIAZOLE DERIVATIVES BEARING 2, 4, 5-TRIPHNENYL IMIDAZOLE MOIETYAbstract
A series of Oxadiazole derivatives (4a-d) have been synthesized from (2, 4, 5-triphenyl-imidazole-1-yl)-acetic acid hydrazide under various reaction conditions. Elemental analysis, IR, 1H NMR and mass spectral data confirmed the structure of the newly synthesized compounds. All the synthesized Oxadiazole derivatives have been investigated for their anti-fungal and antimicrobial activity showing moderate to good activity. The anti-fungal activity of the newly synthesized compounds was compared with the standard drug Voriconazole. The oxadiazole derivatives showed moderate to good ant-fungal activity. The compounds having 4-methoxy group showed good activity (81%). The Oxadiazole derivative having 4-flourophenyl group showed highest activity (82.14%). The results of anti-microbial and anti-fungal activity clearly indicated that oxadiazole ring bearing 2, 4, 5-triphneylimidazole have moderate activity.
Iftikhar Ahsan *¬ and Kaushal K.Chandrul
Pharmaceutical Sciences, Research Centre, Shri Venkateshwara University, Gajraula, (U.P.), India
03 June, 2015
14 September, 2015
24 October, 2015
01 November, 2015