ANTIMICROBIAL AND CYTOTOXIC ACTIVITIES OF TINOSPORA CORDIFOLIA (FAM: MENISPERMACEAE)Abstract
Tinospora cordifolia, belonging to the Menispermaceae family, has been investigated for isolation of its secondary metabolites and evaluation of biological activities with special emphasis to the antimicrobial screening and cytotoxic study. The crude methanolic extract of Tinospora cordifolia along with its Pet ether, carbon tetrachloride, and chloroform soluble fractions were subjected to microbiological investigation by the disk diffusion method. The CCl4 soluble fraction was found to have mild to moderate anti-microbial action. In the brine shrimp lethality bioassay, the Pet ether, CCl4, chloroform and aqueous soluble fractions of crude methanolic extract were found to show LC50 1.918 mg/ml, 0.402mg/ml, 0.691 mg/ml and 2.246 mg/ml respectively. This indicated that the carbon tetrachloride and chloroform fractions were highly cytotoxic.
Md. Hanif Uddin, Md. Aslam Hossain and Md. Hassan Kawsar*
Associate Professor, Department of Pharmacy, Faculty of Pharmacy, Dhaka International University, Dhaka, Bangladesh
09 November, 2010
27 January, 2011
16 February, 2011
01 March, 2011