ANTIMICROBIAL, CYTOTOXICITY AND ANTIOXIDANT ACTIVITIES FROM THE STEM OF RAVENIA SPECTABILIS LINDL.Abstract
Aim of this study was to determine the Antimicrobial, Cytotoxicity and Antioxidant activities of the stem of Ravenia spectabilis. For this study, the dried stem’s powder of Ravenia spectabilis was subjected to cold extraction with methanol and partitioned with n-hexane, carbon tetrachloride and chloroform. The crude methanolic extracts and its n-hexane, carbon tetrachloride, chloroform soluble partitionates, some column fractions and isolated one pure compound (g-fagarine) demonstrated mild to moderate antimicrobial activity against a wide range of Gram-positive and Gram-negative bacteria and fungi. The extractives showed significant cytotoxic activity when tested by brine shrimp lethality bioassay. In addition, the extractives also exhibited significant free radical scavenging activity when compared with the standard drug Tert– butyl-1-hydroxytoluene (BHT).
Md. Mozammel Haque , Sufia Begum Md. Hossain Sohrab , Monira Ahsan , Choudhury Mahmood Hasan*, Nuruddin Ahmed
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh
05 July, 2012
07 October, 2012
24 November, 2012
01 December, 2012