ANTINOCICEPTIVE AND ANTIDIARRHEAL PROPERTIES OF THE ETHANOLIC EXTRACT OF MANILKARA ZAPOTA (LINN.) BARKAbstract
Aim of the study: The present study was designed to investigate the analgesic and antidiarrhoeal activities of the ethanolic extract from the bark of Manilkara zapota (Linn.).
Material and methods: The analgesic activity was evaluated in acetic acid induced writhing model and the antidiarrhoeal activity was evaluated in castor oil induced diarrhoea model in white albino mice (Swiss-webstar strain).
Resuts: Phytochemical analysis of the ethanolic extract of the bark of M. zapota indicates the presence of reducing sugar, tannins, steroid, saponins & gum of compounds. The ethanolic extract of M. zapota has effect on acetic acid induced writhing in mice. At the dose of 250 mg/kg & 500 mg/kg of body weight, the extract produced 38.55% & 56.42 %writhing inhibition in test animals respectively. The results are statistically significant (P <0.001) and is comparable to the standard drug Diclofenac Na, which showed 72.07% at a dose of 25 mg/kg weight. The extract has also effect on castor oil induced diarrheal method in mice. The result show that extract inhibited the mean number of defecation which were 29.31% (P<0.01) and 41.37% (P<0.001) at the doses of 250 mg/kg and 500 mg/kg respectively. The latent period for the extract treated group (p<0.001 & P<0.01) increase respectively as compared to control group.
Conclusion: The present study tends to suggest the antinociceptive and antidiarrheal activities of the crude ethanolic extract of the bark of M. zapota and justify its use in folkloric remedies.
Hemayet Hossain*, Md. Sariful Islam Howlader , Shubhra Kanti Dey , Arpona Hira and Arif Ahmed
Senior Scientific Officer, Chemical Research Division, BCSIR Laboratories, Dhaka, Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka-1205, Bangladesh
30 July, 2012
01 October, 2012
24 November, 2012
01 December, 2012