ANTIOXIDANT ACTIVITY OF CASSIA AURICULATA AND CASSIA FISTULA EXTRACT ALONG WITH WOUND HEALING ACTIVITY OF ITS POLYHERBAL FORMULATIONAbstract
Due to emergent concerns about unhealthy consequences of chemicals in the health industry, the interest towards natural and herbal substances has been growing every day. In this study, the antioxidant effect of Cassia fistula [CFF] and Cassia auriculata [CAF] extract was evaluated. Also discover wound healing activity of polyherbal formulation (CFF and CAF). The antioxidant activity of the extract was evaluated by using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity. Total phenolic content (TPC) was determined to screen the prepared extracts by using the Folin-Ciocalteu phenol reagent method. The polyherbal formulation (CFF and CAF) using the excision wound model. The CFF and CAF extracts showed variable degrees of antioxidant activity. The formulated gel accelerates the wound healing process which may be due to enhancing the cellular defense mechanisms, proliferation, suppression of inflammation, and contraction of the collagen tissue and could be delayed by reactive oxygen species or microbial infection. The results suggest that extracts have antioxidant properties, which may be a potentially promising agent and favorable for wound healing, and this plant extract used in polyherbal formulation may be useful in the management of abnormal healing.
S. M. Kewatkar *, V. V. Paithankar, S. S. Deshpande, S. P. Jain and D. H. Nagore
Rajarshi Shahu College of Pharmacy, Buldana, Maharastra, India.
23 March 2020
04 July 2020
15 July 2020
01 March 2021