ANTIOXIDANT ACTIVITY OF RUBIA CORDIFOLIA AGAINST LEAD TOXICITYAbstract
To evaluate the in vivo antioxidant activity of alcoholic extract of the roots of Rubia cordifolia (RC). Male mice, were exposed, either to a diet containing 40mg/kg body weight of Pb nitrate or combined with Rubia cordifolia for the first period of 40 days, where the animals were sacrificed for oxidative studies. Ingestion of Pb (NO3)2 was significantly decreased RBC count, WBC count, Hb level and serum total protein contents in the mice. But, serum Alanine Transaminase, Aspartate Aminotransferase, and cholesterol level were significantly increased after implication of this metal. However, oral administration of Rubia cordifolia, to lead treated mice led to marked improvement in both hematological and serum biochemical changes. Rubia cordifolia alone had moderate effect on mice, where as co-administration of lead nitrate with Rubia cordifolia reversed the effect of lead.
Shweta Lodia* and Leena Kansala
Department of Bioscience and Biotechnology, Banasthali University, Banasthali, Rajasthan, India
14 March, 2012
19 June, 2012
26 June, 2012
01 July 2012