ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITY OF CRUDE FLAVONOID FRACTION OF MITRAGYNA PARVIFOLIAAbstract
Inflammation is considered a primary physiologic defense mechanism that helps the body to protect itself against infection, burn, toxic chemicals, allergens, or other noxious stimuli. Inflammatory diseases are currently treated with steroidal and non-steroidal anti-inflammatory drugs (NSAIDs). Unfortunately, both of these widely prescribed drug classes have significant negative side effects. Hence, there is a need to develop new drugs with novel modes of action that do not produce considerable side effects. The use of traditional medicine and medicinal plants in most developing countries as a normative basis for the maintenance of good health, has been widely observed. So, crude flavonoid fraction of Mitragyna parvifolia was screened for anti-inflammatory activity using Carrageenan induced method and Formalin induced method at various doses (50,100 &200 mg/kg), and the results were compared with standard drug diclofenac sodium (20 mg/kg). It showed significant activity at 200 mg/kg. The Crude flavonoid fraction was also screened for antioxidant activity at various concentrations (20, 40, 60, 80,100μg/ml) using the DPPH free radical scavenging method. The antioxidant activity was concentration-dependent which was compared with standard antioxidant ascorbic acid. The highest antioxidant activity of CFF of M. parvifolia was observed at a concentration of 100μg/ml.
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Vishveshwarya Group of Institutions, G.T. Road, Dadri, Greater Noida, Uttar Pradesh, India.
27 January 2022
06 March 2022
27 April 2022
01 September 2022