ANTIOXIDANT AND ANTIARTHRITIC ACTIVITY OF ALLICIN IN ANIMAL MODELSAbstract
Inflammation is common and essential protective response to the harmful stimuli such as infectious agents, antigen-antibody reactions, thermal, chemical, and physical agents, and ischemia. The oxidative stress is produced by free radicals, predominately reactive oxygen species (ROS), which cause tissue damage from oxidative stress. Antioxidants play an important role in neutralizing such free radicals. Research in recent decades has shown widespread pharmacological effects of A. sativum and its organosulfur compounds especially Allicin. Studies carried out on the chemical composition of the plant show that Allicin is an important constituent of the plant and is the most important alkaloid that is generally claimed to be responsible for their beneficial effects which is known to possess antioxidant and anti-arthritic activity. Hence an attempt was made to investigate its antioxidant and anti-arthritic potential.
M. K. Jayanthi *, Sushma Naidu V., Pramod and Sunil
Department of Pharmacology, JSS Medical College, JSS University JSS Nagar, Mysore-570015, India
16 July, 2014
28 September, 2014
01 December, 2014
01 March, 2015