ANTIOXIDANT AND HAEMATOPROTECTIVE ACTIVITY OF THE SARACA INDICA STEM BARKAbstract
Present study was designed to evaluate the antioxidant and hematoprotective activity of methanolic extract of saraca indica bark. Antioxidants and hematoprotective effect of saraca indica bark may be due to its polyphenolic compounds. Polyphenols act as reducing agents via scavenging of free radicals and chelation of transition metals. The hematoprotective activity of Saraca indica was studied in Phenylhydrazine induced anemic rats. Anemia was induced by an oral administration of Phenylhydrazine for a period of 7 days. Hgb concentration, RBC count, PCV, MCH, MCHC were analyzed as indices of anemia. Phenylhydrazine significantly decrease the Hgb, RBC and increased MCV and WBC. The Saraca indica was administered at the dose levels of 200mg/kg, 400mg/kg orally to the animals for 14 days. After 14 days of treatment with Saraca indica at the dose level of 400 mg/kg significantly reverse the above parameters and turn towards the normal value. These results support the traditional use of Saraca indica in the treatment of anemia.
C. K. Dubey, A. K. Meena, V. Mishra, P. Singh, F.W. Bansode and R. K. Singh
Division of Toxicology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India
10 April, 2014
11 February, 2015
20 March, 2015
01 April, 2015