ANTIOXIDANT POTENTIAL OF THE WHOLE PLANT EXTRACT OF MOLLUGO PENTAPHYLLA LINN. ON ETHANOL INDUCED LIVER DAMAGEAbstract
The potential antioxidant effect ethanol induced liver damage was investigated using crude methanolic extract of the whole plant of Mollugo pentaphylla Linn. The standard drug used was ascorbic acid mg / kg/day. Serum cholesterol, triglycerides aspartate amino transferase (AST) and alanine amino transferase (ALT) levels were measured as antioxidant indicators. There was a significant reduction in the elevated serum enzymes, triglycerides and total cholesterol levels. The histopathologial studies revealed that the liver cells undergoing hydrobic and fatty changes indicating hepato cellular damage in the case of ethanol administration while extract treated animals showed mostly normal hepatocytes and mild hydrobic changes. Hence the study concluded that the plant exhibits antioxidant property.
R. Valarmathi*, A. Rajendran , S. Akilandeswari and K. Tejaswi
Assistant Professor, Periyar College of Pharmaceutical Sciences, K. Sathanoor Road, Tiruchirappalli- 620 021, Tamil Nadu, India
14 July, 2011
18 August, 2011
19 October, 2011
01 November, 2011