ANTIOXIDANT POTENTIAL OF TRAGIA INVOLUCRATA LINN ON STREPTOZOTOCIN INDUCED OXIDATIVE STRESS IN RATSAbstract
In Traditional Ayurvedic system of treatment Tragia involucrata Linn. is intended to use for diabetic patients has been screened for antioxidant activity. For antioxidant studies, aqueous ethanolic extract of Tragia involucrata (AEETI) was administered orally for 28 days at a dose of 250 and 500 mg/kg body weight to Streptozotocin- Nicotinamide induced Wistar rats. All the animals were sacrificed on the 29th day and the levels of LPO, SOD, CAT, GPx and GSH in kidney and liver of control and experimental rats were studied. The AEETI exhibited significant antioxidant activity showing increased levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH) and decreased level of lipid peroxidation. These results showed that treatment with AEETI lowers Streptozotocin induced LPO and alters SOD, CAT, GPx and GSH enzymes to reduce oxidative stress.
S. Mohamed Farook* and W. Clement Atlee
Department of Pharmacology, C. L. Baid Metha College of Pharmacy, Thuraipakam, Chennai, Tamil Nadu, India
08 March, 2011
29 March, 2011
17 May, 2011
01 June, 2011