ANTIPARKINSONIAN ACTIVITY OF HYDROALCOHOLIC EXTRACT OF THE STEMS OF CAPPARIS DECIDUA (FORSSK.) EDGEW.Abstract
The goal of the research is to analyze the antiparkinsonian activity of hydroalcoholic extract of the stems of Capparis Decidua (HECD). Themost common neurodegenerative condition which stand second is Parkinson. It is reported by dopaminergic neuron loss in the striatum’s substantia nigra & dopamine loss (DA). Capparis Decidua plant is used as anti-inflammatory, laxative, anti-diabetic, anthelmintic, antibacterial, astringent, digestive and for so many other traditional use, we used this research to scientifically verify Parkinson behaviour using suitable animal models. In mice, using haloperidol (1 mg/kg i.p) catalepsy was induced. Bromocriptine (2.5 mg/kg) and HECD were administered orally to the treatment group at the dose of 100 mg/kg, 200 mg/kg, and 300 mg/kg. Bar tests for catalepsy, motor coordination tests by rotarod, and locomotor activity by actophotometer were performed to evaluate behavioural changes. Dopamine and catalase assay were also carried out to assess biochemical parameters. Using standard as ascorbic acid in UV visible spectrophotometer, evaluation of antioxidant activity by DPPH radical scavenging method were performed. The outcome of our work indicates that the hydroalcoholic extract possesses antiparkinsonian activity. It can be reported that because of its antioxidant activity and presence of flavonoids, alkaloids, and polyphenols that may be essential for antiparkinsonian effect, it can be indicated that they may have played an important a role in the treatment.
Shaheen Khan * and Imtiyaz Ansari
Department of Pharmacology, Oriental College of Pharmacy, Navi Mumbai, Maharashtra, India.
19 October 2020
07 February 2021
23 June 2021
01 October 2021