ANTIPARKINSONIAN EFFECTS AND MECHANISTIC INSIGHTS OF SOME INDIGENOUS HERBAL FORMULATIONSAbstract
Objective: The anti-parkinson’s potential of the formulations containing roots of Withania somnifera family Solanaceae, leaves of Ocimum sanctum family Lamiaceae, and rhizome of Curcuma longa family Zingiberaceae, was investigated in reserpine and haloperidol induced parkinson’s model. Materials and Methods: Parkinson’s was produced by Reserpine and Haloperidol administration (1mg/kg i.p and 1mg/kg i.p. respectively). Formulation (300 mg/kg orally) was administered as pretreatment for 14 days. The animals were evaluated for Behavioral and Locomotors activity. Results: Pretreatment with the formulations significantly (P < 0.01) protected the catalepsy, rigidity from the toxic effects of reserpine and haloperidol. The hydroalcoholic extract formulation of Ashwagandha, Tulsi and Haldi was assigned to class 5 (LD50> 2000mg/kg), were recommended by OECD. Conclusion: These results suggest an anti-parkinson’s effect of formulations due to its nerve tonic, &increases in dopamine concentration.
Tanvi Pingale* and Kedar Prabhavalkar
Department of Pharmacology, Dr. Bhanuben Nanavati College of Pharmacy, Mumbai, MS, India
12 May, 2015
, 17 June, 2015
11 September, 2015
01 November, 2015