ANTIPLASMODIAL ACTIVITY OF AGANOSMA CYMOSAAbstract
Ethylacetate leaf extract of Aganosma cymosa was screened for antimalarial activities in-vivo in rats inoculated with red blood cells parasitized with Plasmodium falcipuram using 4-day Suppressive test and Rane’s test. The result of mean parasitemia by 4-day Suppressive test for the Group AC600, AC400 & AC200 was 4.62 ± 3.63, 13.34 ± 2.42, 19.29 ± 3.23 and percentage suppression were 80.1%, 42.54% and 16.9% respectively. However, standard drug chloroquine (15 mg/kg) was found to exert a considerable lower percentage parasitemia of 2.73 ± 1.6 and higher percentage suppression of 88.24%. From the results of the Ranes test, the parasitemia levels on day 7 for AC200, AC400, AC600 were 16 ± 0.4, 12 ± 0.4 and 2 ± 0.6 and the percentage inhibition was found to be 23.80, 45.45 and 65 respectively. While the chloroquine treated group had a mean parasitemia 6 ± 0.2 and percentage inhibition of 70%.The plant extracts showed significant dose-dependent antiplasmodial activity with the decrease in parasitemia, rectal temperature, body weight and increase in suppression, packed cell volume in all treated groups viz. AC200, AC400 & AC600 when compared to standard chloroquine and control groups by both the models.
M. S. Reddy and B. R. Kuber *
Department of Pharmacognosy, Institute of Pharmaceutical Technology, Sri Padmavathi Mahila Visvavidyalayam, Tirupathi, Andhra Pradesh, India.
11 April 2019
22 August 2019
02 September 2019
01 January 2020