ANTIPROLIFERATIVE ACTIVITY OF TRAPA ACORNIS SHELL EXTRACTS AGAINST HUMAN BREAST CANCER CELL LINES
AbstractEvaluation of the anticancer effect of Trapa acornis (Family- Trapaceae) which has long been prescribed for various infectious and malignant diseases. The shells extract of Trapa acornis has been carried out by following due procedure. Cell lines, cultures were incorporated and procured for in-vitro and in-vivo study with reference to cell proliferation assay, cell viability assay and cell cycle analysis. Bio-assays of extracts from Trapa acornis showed that a fraction (fraction 3) from an ethanolic extract had an anticancer effect on SKBR3 and MDA-MB435 human breast cancer cells. In MDA-MB435 cells, cell cycle analysis showed that the plant extract fraction 3 induced the accumulation of cells in G2/M phase, whereas no significant change in cell cycle was detected in SKBR3 cells. The results indicated that the extract fraction could induce cell cycle arrest in some way. However, further investigation is needed to assess the molecular mechanisms mediated anticancer activities of this plant
Article Information
18
2238-2243
422KB
1112
English
IJPSR
D. Pradhan* and G. Tripathy
University Department of Pharmaceutical Sciences, Utkal University, Bhubaneswar -751004, Orissa, India
deba_udps@yahoo.co.in
15 December, 2013
06 February, 2014
25 April, 2014
http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2238-43
01, June 2014
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