ANTIRHEUMATOID ACTIVITY OF AQUEOUS EXTRACT OF PIPER LONGUM ON FREUNDS ADJUVANT-INDUCED ARTHRITIS IN RATSAbstract
Aqueous extract of the fruits of the plant Piper longum was studied for their Anti rheumatoid activity in Freunds Adjuvant Induced Arthritis Rats with the dose of 200 and 400 mg/kg p. o. The administration of extract reported significant reduction in paw swelling on 4th, 8th, 14th and 21st day after sub-plenter administration of Complete Freunds adjuvant. The paw swelling was measured as a volume displacement using digital Plethysmometer. Furthermore, these results supported by radiographic analysis of affected knees of rats. From the results observed in the present investigation, it may be concluded that the aqueous extract of P. longum possesses potentially useful anti-arthritic activity in Complete Freunds Adjuvant model.
Subhash R. Yende*, Vrushali D. Sannapuri, Niraj S. Vyawahare and Uday N. Harle
Department of Pharmacology, Guru Nanak College of Pharmacy, Nari, Nagpur (MS) India
23 May, 2010
29 July, 2010
28 August, 2010
15 September, 2010