ANTITUMOR POTENTIAL OF STANDARDIZED EXTRACT FROM AEGLE MARMELOS ROOT ON DALTON’S LYMPHOMA INDUCED MICE MODELAbstract
The antitumor property of the successive, standardized methanolic (MeOH) extract of Aegle marmelos roots (MAM) was investigated in Dalton’s ascites lymphoma mice model. Materials and methods: Flavonoid present in MAM was quantitatively estimated using high performance thin layer chromatography. MAM (100, 300 mg/kg) was administered orally for 15 days to assess antitumor activity. The tumor was induced by DAL cell lines. The mean survival time (MST) and status of the antioxidant enzymes were analysed, 5 fluoro uracil (5FU) was used as standard drug. Results and discussion: Quercetin content in MAM was found to be as 208 mg/gm with the linearity range 200-800 ng. MAM treated tumor bearing mice exhibited significant (p<0.05) increase in the mean survival time. There was a significant improvement in the super oxide dismutase (SOD), catalase levels and (p<0.01) reduction in lipid peroxidation and nitrous oxide (p<0.01) levels were observed with the MAM treatment in comparison to vehicle treated tumor bearing mice.
G. Syamala *, M. Ramanthan. and S. P. Dhanabal
Associate Professor PSG College of Pharmacy, Peelamedu, Coimbatore -641004
21 September, 2014
20 November, 2014
19 January, 2015
01 May, 2015