ANTIUROLITHIATIC ACTIVITY OF LEAF EXTRACTS OF SYZYGIUM JAMBOS (L.) ALSTON AND ITS ZINC NANOPARTICLES: AN IN-VITRO AND IN-VIVO APPROACHAbstract
Urolithiasis is one of the painful urologic disorders that occurs in approximately 12% of the global population. Syzygium jambos (L.) Alston (Family: Myrtaceae), commonly known as Rose apple in English and Bogijamun in the Assamese, is an important medicinal plant found extensively in Assam and in the Indian continent. Scientific studies confirmed that the extracts of various parts possess anticancer activity, antioxidant, analgesic, antimicrobial activities, and anti-inflammatory properties. Phytochemical and Pharmacological evaluation of the Plant was carried out with special reference to antiurolithiatic activity. The in -vitro evaluation was done using growth inhibition study of struvite crystals, and in-vivo evaluation was done by Ethylene glycol induced urolithiatic model in rats. Our investigation showed that leaf extracts and ZnO-NPs prevented the growth of urinary stones. Further studies should be done to understand pharmacological action and its possible mechanism through elaborate preclinical experimentation and clinical trials in preventing urolithiasis in susceptible populations.
K. Deka *, B. B. Kakoti and M. Das
Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam, India.
01 January 2020
07 April 2020
10 April 2020
01 January 2021