ANTIUROLITHIATIC EFFECT OF VARIOUS WHOLE PLANT EXTRACT OF AGERATUM CONZOIDES LINN. ON ETHYLENE GLYCOL INDUCED UROLITHIASIS IN MALE WISTAR ALBINO RATSAbstract
In the present study antiurolithic activity of various extract of the whole plant of Ageratum consider Linn. was investigated on experimentally urolithiasis induced male albino wistar rats. Urolithiasis was induced in animals by using ethylene glycol (5% v/v, 2ml/rat/7days). Experimental induction of hyperoxaluria results in the rapid formation of calcium oxalate crystals in the renal tubules of experimental animals. The investigation was done based on estimation of stone-forming constituents oxalate, calcium, and phosphate, in kidney and urine. Treatment with ethyl acetate, ethanol and aqueous extract (500mg/kg, p.o) of Ageratum conzoides, the standard group treated with calculi (500mg/kg, p.o) and a positive control group treated with the only saline. The results are compared with calculi, ethanolic extracts, and ethyl acetate extract are significantly lowered the increased levels of oxalate, calcium, and phosphate in urine and also significantly reduced their retention in the kidney. The presented data indicate that administration of Ageratum conzoides extracts decrease urolithiasis and also prevented the formation of urinary stones; it proves the antiurolithiatic activity of the plant.
Department of Pharmacology, Sankaralingam Bhuvaneshwari College of Pharmacy, Sivakasi, Tamil Nadu, India.
04 April 2014
22 May 2014
17 July 2014
01 October 2014