APPLICATION OF DESIGN OF EXPERIMENTS FOR OPTIMIZATION OF RANEY NICKEL MEDIATED BORROWING HYDROGEN REACTIONAbstract
An efficient, cost effective use of Raney nickel (R-Ni) a widely used industrial catalyst for N-Alkylation using alcohols is highlighted here. The work describes the scope and capability of R-Ni in borrowing hydrogen reactions for Aniline and Benzyl alcohol. The reaction optimization is described using two techniques, Conventional and Design of experiment. The use of DOE for reaction optimization is an unique option described in this paper.
Astha Mehta , A. Thaker , V. Londhe and Santosh R. Nandan *
Ambernath Organics Pvt ltd, 307/314, Creative Industries Premises, Road No.2, Sunder Nagar, Kalina, Mumbai-400098, India.
18 June, 2014
28 August, 2014
17 October, 2014
01 February, 2015