APPLICATIONS OF CE-MS IN PHARMACEUTICAL FIELDAbstract
Capillary Electrophoresis–Mass Spectroscopy (CE-MS) is a hyphenated technique as it combines the advantages of both CE and MS. It provides high-resolution separations with high detection selectivity and sensitivity, which allows detailed characterization of many biomolecules in a single analysis. CE-MS improves the ability to deal with the analysis of complex biological samples containing trace amounts of analytes. CE coupled MS has become a widely used analytical technique in fields such as proteomics, metabolomics, and genomics. It is also increasingly used in various other fields like environmental science, food analysis, biotechnology and forensic science etc. However, the development of online CE-MS is not without challenges. Understanding of CE, the interface setup, ionization technique and mass detection system is important to tackle problems while coupling capillary electrophoresis to mass spectrometry. In this article, instrumentation details of CE-MS, the technical aspects of CE‐MS interface, applications and the advancements made in recent years are discussed.
K. Bhavyasri * and G. Mounika
Department of Pharmaceutical Analysis, RBVRR Women’s College of Pharmacy, Hyderabad, Telangana, India.
25 April 2019
11 January 2020
27 January 2020
01 February 2020