APPROACHES TO PULMONARY DRUG DELIVERY SYSTEMSAbstract
Pulmonary route have been used to treat various respiratory diseases for centuries. Ancient inhalation therapies included the use of leaves from plants, vapors from aromatic plants, balsams, and myrrh. The pulmonary route has gained increasing importance in the recent times due to its unique properties such as a large absorptive area of up to 100m2; extremely thin 0.1 μm – 0.2 μm absorptive mucosal membrane and good blood supply. New dispersible formulations and drug aerosol delivery devices for inhalable peptides, proteins and various small molecules have, in the past decade, become of increasing interest for the treatment of systemic and respiratory diseases. This review enlightens the concept of pulmonary drug delivery and the recent advances in the field.
P. Tangri* and S. Khurana
DIT-Faculty of Pharmacy, Mussoorie Diversion Road, Bhagwantpura, Dehradun-248001, Uttarakhand, India
17 March, 2011
18 April, 2011
18 June, 2011
01 July, 2011