ASSAY OF ANTIBACTERIAL DRUG MEROPENEM IN PHARMACEUTICALS BY VOLTAMMETRIC TECHNIQUESAbstract
In present study the electro-oxidative behaviour and determination of meropenem at a glassy carbon electrode were investigated using cyclic, differential pulse anodic adsorptive stripping voltammetry (DPAAdSV) and square wave anodic adsorptive stripping voltammetric (SWAAdSV) techniques. The dependence of the peak current and peak potentials on pH, concentration and scan rates were examined. The oxidation of meropenem gave a well-defined single irreversible peak at glassy carbon electrode vs Ag/AgCl (3M KCl) reference electrode. The oxidation process was diffusion controlled. A linear response was obtained between 1.0 x10-6to 4.0x 10-5 M in aqueous media for differential pulse and square wave techniques. The recovery studies were also achieved to check sensitivity and selectivity of the proposed methods. The proposed methods were applied for the determination of meropenem from pharmaceutical dosage forms without any time-consuming extraction, separation, adsorption steps. The value of LOD was achieved 1.27×10-7 M and 2.24×10-7 M for DPAAdSV and SWAAdSV respectively.
K. K. Jhankal, A. Sharma, Ramswaroop and D. K. Sharma*
Faculty of Science, Department of chemistry, University of Rajasthan, Jaipur - 302004, Rajasthan, India
26 November, 2014
01 February, 2015
18 May, 2015
01 July, 2015