ASSESSING THE FLOATING DRUG DELIVERY SYSTEM USING THE MODEL ANTI-DIABETIC DRUG GLIMEPIRIDEAbstract
Floating drug delivery systems can increase the gastric retention time by manufacturing the systems with a density less than the gastric contents of the stomach. This causes the system to float over the gastric contents in the stomach without affecting the gastric emptying rate for a prolonged period. Glimepiride was selected as a model drug to increase oral bioavailability and efficacy. Hydroxypropyl methylcellulose (HPMC) and Carbopol, which are hydrophilic swellable polymers, govern the drug release from the prepared floating tablets. Buoyancy was achieved by using sodium bicarbonate as a gas-generating agent. The optimized formulation F5 showed a drug release of 42.14% within 12 hrs, whereas the floating lag time was found to be 50 seconds. The formulation variations were made in HPMC and Carbopol concentrations. The dissolution study revealed that sustain release profile can be achieved by increasing polymers concentrations in the formulation. The current study confirms that HPMC and Carbopol with sodium bicarbonate as a gas generating agent can develop floating systems that can provide controlled drug release for an extended duration, thereby achieving prolonged action of drug, enhancing oral absorption bioavailability.
Bhargab Jyoti Sahariah, Ibadahun Lyne Gatphoh, Apurba Talukdar, Manoj Kumar Deka, Ripunjoy Bordoloi and Chanam Melody Devi *
NETES Institute of Pharmaceutical Science, NEMCARE Group of Institutions, Mirza, Assam, India.
29 December 2021
03 February 2022
02 May 2022
01 August 2022