ASSESSMENT OF ANTIMICROBIAL AND CYTOTOXIC ACTIVITIES OF ETHANOLIC EXTRACT OF LEAVES OF ACALYPHA HISPIDAAbstract
The ethanolic extract of leaves of Acalypha hispida was evaluated for phytochemical, cytotoxic and antibacterial activities. Phytochemical studies revealed the presence of flavonoids, saponins, glycosides, reducing sugars and steroids. Cytotoxic activity was investigated by brine shrimp (Artemia salina) lethality assay. The extract showed potent cytotoxic effect (LC50 19.95µg/ml) which is comparable to standard cytotoxic drug chloramphenicol (LC50 7µg/ml). Antibacterial activity was tested by disk diffusion method. The extract exhibited significant antibacterial activity against Salmonella typhe and moderate activity against Enterococcus coli, Streptococcus saprophyticus and Streptococcus agalactin whereas Shigella dysentery found resistant at 250µg/disc and 500µg/disc.
B. Bokshi*, M.A.S. Sayeed, M.I. Ahmed, U.K. Karmakar, S.K. Sadhu
Pharmacy Discipline, Life Science School, Khulna University, Khulna-9208, Bangladesh
10 February, 2012
02 April, 2012
22 May, 2012
01 June, 2012