ASSESSMENT OF ANXIOLYTIC POTENTIAL OF SPIRULINA PLATENSISAbstract
Spirulina platensis, planktonic blue-green algae, has been used as a source of protein (60-70%) and vitamin supplement for more than 15 years without any unknown adverse events. Traditionally, Spirulina platensis has been used as an antioxidant agent. However, no pharmacological work has been done to evaluate the anti-anxiety activity. The present study was premeditated for the evaluation of the anti-anxiety activity of Spirulina platensis. Elevated plus maze (EPM) and light-dark models were used to evaluate the anti-anxiety potential of Spirulina platensis in Swiss albino mice. Albino mice were treated orally with diverse doses of the Spirulina platensis (i.e., 300 and 400 mg/kg). Diazepam (2 mg/kg, IP) was used as a standard drug. In conclusion, 400 mg/kg dose of Spirulina platensis showed significant anti-anxiety activity (P<0.05) while the control group was near to standard group. It concludes that Spirulina platensis could be useful as an anti-anxiety agent for prospects.
S. Neekhra, V. Jain, P. Jain, S. Jain, S. A. Jain, N. K. Garg, A. Jain and A. Jain *
Bhagyoday Tirth Pharmacy College, Sagar, Madhya Pradesh, India.
10 March 2014
07 May 2014
07 June 2014
01 September 2014