ASSOCIATION OF CEFTRIAXONE RESISTANCE WITH CLINICAL OUTCOMES AMONG CRITICALLY ILL PATIENTS ADMITTED WITH BACTERIAL INFECTIONS

Background: The rise in antibiotic resistance has rendered many antibiotics less effective, making it increasingly challenging to treat infections. Objectives: The objectives of this study were to determine the association between ceftriaxone resistance and in-hospital mortality and length of hospital stay among critically ill patients with bacterial infections and to analyze ceftriaxone resistance patterns among patients with bacterial infections. Methods: A written informed consent was taken from participants who fulfilled inclusion criteria and were willing to participate. Demographic profile and clinical characteristics of participants were documented. Results: The duration of hospital stay in ceftriaxone sensitive group and ceftriaxone resistant groups was represented as mean ± SD (in days), in ceftriaxone sensitive group it was 9.73 ± 3.66 days and in ceftriaxone resistant group it was 16.00 ± 11.06 days. The patients in the ceftriaxone resistant group had a longer hospital stay. On comparing the clinical outcome between the two groups the survival rate was better in ceftriaxone sensitive group. Conclusion: The clinical outcome and duration of hospital stay between the ceftriaxone sensitive group and ceftriaxone resistant group was statistically significant and this indicated that the patients in the ceftriaxone sensitive group had a shorter hospital stay and better clinical outcome than ceftriaxone resistant group.