ATTENUATION OF INFLAMMATION BY ETHANOLIC EXTRACT OF CAESALPINIA BONDUCELLA USING IN-VITRO INFLAMMATORY MODELSAbstract
Background: Caesalpinia bonducella F. (Leguminosae) has long been used in traditional medicinal treating methods. It has high therapeutic values in India Ayurveda. They contain tannin, saponins, flavonoids, and alkaloids. The seeds of Caesalpinia bonducella are claimed to be styptic, purgative, anthelmintic and cures inflammations. Today the interest in traditional medicine and demand for more plant-based drugs has increased. Here the study is focused on anti-inflammatory efficiency and analysis of phytochemical compounds from the Caesalpinia bonducella seed kernel extract. As part of the immune response, inflammation plays a significant role in defending or protecting the body against pathogens like viruses, bacteria, fungi, and other parasites. Inflammation leads to a complete detriment at the sites of inflammation and promotes the renewal or regeneration of normal tissues. During inflammation, Chemotaxis is the event with cells like Fibroblasts, leukocytes, Macrophages, and Tumor cells are involved in the migration of cells towards a chemical signal in the cell’s surrounding environment. Our research focuses on unravelling the anti-inflammatory efficacy of ethanolic fraction, which comprises the active leads necessary for fighting against inflammation. The main part of this research project is to carry out an ethanolic extract of Caesalpinia bonducella seed kernel and the in-vitro assessment of the anti-inflammatory effects of plant extract.