BACTERIOPHAGE MEDIATED MODULATION OF GUT MICROBIOME RESPONSIBLE FOR COLORECTAL CANCERAbstract
The gut microbiome composition directly correlates with the disease’s development and thus with an individual’s health. According to the published scientific literature, gut microbiota is directly linked with developing diseases such as colorectal cancer. On the other hand, Bacteriophages are the group of viruses that infects the bacterial cells typically and can be utilized to manage the dysbiosis of the gut’s microbial population. Here the major focus of this review is to know the applications and processes of bacteriophages in modulating the gut microbiome. According to studies, the modulation of the gut microbiome using bacteriophages has yielded good results. Although a major issue using this technique to modify the gut microbiome is regarding the survival of the phages when coming in contact with the stomach’s highly acidic environment. Consequently, effective phage encapsulation is required. Thus, in this review, we focus on treating colorectal cancer using bacteriophage-mediated modulation of the gut microbiota.
Sutripto Ghosh and Tamalika Chakraborty *
Department of Biotechnology, Guru Nanak Institute of Pharmaceutical Science and Technology, Kolkata, West Bengal, India.
06 June 2022
22 July 2022
04 August 2022
01 February 2023