BEYOND BEAUTY: THE MOLECULAR SCIENCE AND CLINICAL EVIDENCE OF ANTI-AGING SKINCARE
AbstractThe anti-aging cosmeceutical industry has transformed from conventional cosmetic applications to biologically active products designed to target the key molecular mechanisms of skin aging itself. The focus of this review is to identify key bioactive ingredients, their mechanisms of action, and delivery systems being used in anti-aging products. The most commonly used bioactives are retinoids, peptides, antioxidants, niacinamide, bakuchiol, glutathione, green tea polyphenols, and hyaluronic acid that provide the anti-aging effect by stimulating collagen, reducing oxidative damage, accelerating epidermal regeneration, and repairing the barrier function of the skin. Recent advances in delivery systems such as liposome delivery systems, nanoparticles, and microneedle delivery systems have greatly increased the stability, bioavailability, and penetration of these bioactive ingredients. The challenges remain regarding the long-term safety efficacy issues, stability of cosmetic formulation, and appropriate regulatory approvals for formulation. The Future research should focus on adopting evidence-based approaches integrating biotechnologies for better skin health and longetivity.
Article Information
3
1375-1395
1767 KB
5
English
IJPSR
Ayesha Siddiqua Gazi *, Umaymah Ahmareen, Aaine Ashfaq and Mehveen Mukaram
Department of Pharmaceutics, Deccan School of Pharmacy, Hyderabad, Telangana, India.
Umaymahahmareen@gmail.com
24 November 2025
30 January 2026
12 February 2026
10.13040/IJPSR.0975-8232.17(5).1375-95
01 May 2026
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