BIOFILM INFECTIONS: A NEW THERAPEUTIC CHALLENGEAbstract
Biofilms are multicellular communities of bacteria. The ability to form biofilm is a universal attribute of bacteria and as bacteria can form biofilm in medical, industrial and environmental settings, it impacts human lives in many different ways. Bacteria undergo profound physiologic, morphologic and genetic changes as the transit from planktonic (free swimming, non-biofilm) form to surface attached biofilms. As bacteria in biofilm exhibit enhanced resistance to antibiotics and clearance by the host immune system, biofilm has been an intensely researched area for microbiologists, immunologists and pharmaceutical scientists alike. This review focuses on current knowledge on biofilm science, clinical relevance and virulence of biofilm, host response to it and therapeutic options to eradicate biofilm.
Department of Medical Microbiology, College of Medicine, University of Hail, PO Box.- 2440, Hail, Saudi Arabia
23 April, 2013
06 August, 2013
14 August, 2013
01 September, 2013