BIOLOGICAL ASPECTS OF NOVEL BENZOTHIAZOLE DERIVATIVESAbstract
The heterocyclic compounds are formed by the hetero atoms (O, S, N, etc.) in the cyclic ring system. These are mainly started from 3- membered to 10- membered heterocyclic rings. The compound containing heterocyclic molecules shows potent activity in various pharmacological targets. Benzothiazole is a fusion of a benzene ring with a 5-membered thiazole ring which is widely used in heterocyclic compounds. The benzothiazole pharmacophore and its derivatives are used for the development of novel drugs and have also shown different pharmacological and biological activities such as anticancer, antibacterial, antifungal, anti-inflammatory, analgesic, anti-HIV, antioxidant, anticonvulsant, antitubercular, antidiabetic, antileishmanial, antihistaminic, antimalarial activities. In previous years, few new benzothiazoles have been shown with different biological responses. In such a manner, this review illuminates the benzothiazole and its substituted product that possesses distinct biological activity. This article discovered a novel benzothiazole-based drug that has shown less toxic and more active effects.
Alpa Verma, Arun Kumar *, Syed Misbahul Hasan, Kuldeep Singh, Bhavana Dubey and Parul Mishra
Department of Pharmaceutical Chemistry, Integral University, Kursi Road, Lucknow, Utter Pradesh, India.
01 June 2022
14 August 2022
27 August 2022
01 March 2023