BIOLOGICAL EVALUATION, SYNTHESIS AND CHARACTERIZATION OF SOME NOVEL MANNICH BASES OF PYRAZOLINE DERIVATIVES
AbstractIn the present investigation, some novel Mannich Bases of Pyrazoline derivatives(7a-g) is synthesized by treating various substituted acetophenones (1a-g) with 6-methaoxy-1-napthaldehyde (2) in alcoholic sodium hydroxide to obtained intermediate Chalcones (3a-g), which was further treated with isonicotinohydrazide (4) to get (3-(4-substituted phenyl)-5-(6-methoxy naphthalen-1-yl)-4, 5-dihydro- 1H-pyrazol-1-yl) (pyridin-4-yl) methanone (5a-g). Further, it is refluxed for 6-10 h. with 4-chloroaniline (6) and formaldehyde in methanol to afford Mannich Bases i.e. (4-(((4-chlorophenyl) amino) methyl) -5-(6-methoxynaphthalen -1-yl)-3-substituted phenyl-4, 5-dihydro- 1H-pyrazol-1–yl )(pyridin-4-yl) methanone (7a-g). The structure of synthesized Mannich bases was confirmed on the basis of Spectral data (IR, 1H NMR, mass, and elemental analysis) and evaluated for the antimicrobial activity. The antimicrobial data revealed that the synthesized derivative possesses very promising to moderate antibacterial and antifungal activity.
Article Information
54
2425-2430
478
801
English
IJPSR
S. B. Jadhav * and P. K. Vibhute
Department of Chemistry, Balbhim Arts, Science & Commerce College, Beed, Maharashtra, India.
orgchem.jadhav@gmail.com
14 December 2019
02 April 2020
04 April 2020
10.13040/IJPSR.0975-8232.11(5).2425-30
01 May 2020
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