BIOLOGICAL EVALUATIONS OF POTENTIAL HERB- NERIUM INDICUM (LINN.)Abstract
The methanolic extract of Nerium indicum showed the presence of alkaloids, tannins, phenols, and starch in phyto-chemical investigation. Total phenolic content of the drug was estimated by Folin Ciocatteu’s method and was found to be 55.20 µg/10 ml. Analgesic activity was performed using three models they are Writhing, Tail-flick activity and Hot plate models. The methanoilc extract showed 44.51% inhibition in Writhing model, 50.09% for 30 sec’s and 62.45% in 60 sec and hot plate method showed 47.31%. Analgesic activity was carried out and the results were encouraging, which stated that the methanolic extract of Nerium indicum showed significant peripheral analgesic activity. The mechanism of analgesic activity action of Nerium indicum may be due to its inhibitiory effect on the synthesis of prostaglandins and leukotrienes.
A. Shah, A. V. Zambare, A. Desai and G. S. Chakraborthy*
SVKM’s, NMIMS, SPTM, Shirpur Campus, Shirpur, Maharashtra, India
17 September, 2010
02 November, 2010
24, January 2011
01 February, 2011