BIOLOGICAL STUDIES OF THE BARK OF ALBIZIA LEBBECK (L.) BENTHAbstract
The phytochemical screening of the bark of Albizia lebbeck (L) showed positive test for tannin, alkaloid, flavonoid, terpenoid, phlabotannin, saponin, steroid and cardiac glycoside. In this article an attempt was made for biological studies (the antimicrobial activity, cytotoxicityand free radical-scavenging activity) of different extracts (hexane, methanol, ethyl acetate, water and butanol extract) of the bark of Albizia lebbeck. The antimicrobial sensitivity of the extracts was tested using the disc diffusion method. The cytotoxic effects of five extracts (hexane, methanol, ethyl acetate, water and butanol extract) of the bark of Albizia lebbbeck were carried out. Free radical scavenging activity of the bark of Albizia lebbeck was performed. All the extracts showed moderate anti microbial activity and gram positive bacteria were more sensitive than gram negative bacteria. Significant cytotoxic activity was noticed and hexane extract was found the most lethal to brine shrimp nauplii. This result revealed that the highest cytotoxic constituent may be non polar in nature. Good free radical scavenging activity was observed in all the extracts, and hexane extract was found be the most potent.
Jerin Tasnim *, Anamika Saha , Shamim Ahmed , Nasim Sultana , Tanvir Muslim and Md. Azizur Rahman
Department of Chemistry University of Dhaka Dhaka-1000, Bangladesh
23 April, 2014
16 June, 2014
31 July, 2014
01 November, 2014