BIOLOGICALLY POTENTIAL FLAVONES: A SUBGROUP OF FLAVONOIDSAbstract
Flavones are an important class of flavonoids having a wide range of biological activities like antioxidant, anti-inflammatory, anti-oestrogenic, antimicrobial, anti-allergic, antioxidant, vascular, antitumor, and cytotoxic activities. First cyclin-dependent kinase inhibitor, flavopiridol, which is a flavone is approved as an orphan drug in Europe for the treatment of relapsed chronic lymphocytic leukemia. So, these structural motifs may show potential activity to wide therapeutic conditions. Thereby synthesis of flavone is an important aspect in medicinal chemistry. This article covers the synthetic strategies available in the literature and their usefulness in terms of yield and reaction condition and the biological activity exerted by the natural and synthetic flavone derivatives and their probable mechanism of action. It is expected that this review may be helpful for medicinal chemist in research regarding flavones with new therapeutic applications.
M. Das *, K. Manna, U. Banik, P. S. Ghosh and P. Sarkar
Department of Pharmacy, Tripura University (A Central University), Suryamaninagar, Tripura, India.
08 March 2014
23 April 2014
07 June 2014
01 September 2014