BIOSYNTHESIS OF SILVER NANO PARTICLES FROM LEUCAS ASPERA (WILLD.) LINK AND ITS ANTI-INFLAMMATORY POTENTIAL AGAINST CARRAGEEN INDUCED PAW EDEMA IN RATS

Synthesis of metal nanoparticles has become an important branch of nanotechnology and there is an increasing commercial demand for nanoparticles due to their wide applications. The present study was carried to synthesize silver nanoparticles (AgNPs) using the ethanolic extract of the Leucas aspera and evaluate its in-vitro anti inflammatory activity. The synthesis was done by using the ethanolic solution of L. aspra extract and AgNO3. The AgNPs were characterized using UV-Spectroscopic analysis, Scanning Electron Microscopy (SEM), Fourier Transform Infra Red Spectroscopy (FTIR) analysis. UV-Vis spectral analysis shows a maximum absorption peak at 421.00 nm. The FTIR spectra of AgNPs exhibited prominent peaks at 3697cm-1,1761cm-1,1390cm-1, 831cm-1 which are associated with OH stretching, C=C stretching, CH stretching respectively. The SEM analysis of the synthesized AgNPs clearly showed the clustered and irregular shapes, mostly aggregated and having the size of 25-80 nm. The synthesized AgNPs exhibited an enhanced anti inflammatory activity due to the synergistic effect of phytoconstituents in L. aspera extract and the silver ions.