BRAIN TARGETING OF WATER SOLUBLE DRUG THROUGH NASAL ROUTE USING FATTY ACID VESICLESAbstract
Fatty acid vesicles are novel vesicles incorporating fatty acids which enhance the brain targeting efficiency when compared to conventional liposomes. This study’s objective was to prepare, characterize, and evaluate fatty acid vesicles for brain targeting of a water-soluble drug, atomoxetine HCl through nasal route. The atomoxetine HCl loaded fatty acid vesicles were prepared by using the reverse phase evaporation method using Phospholipon 90 H, oleic acid, and ethanol. Prepared formulations were evaluated for parameters like particle size (152.9 nm), drug entrapment (90.4%), zeta potential (-9.41 mv), and in-vitro release was found to be 98% up to 4 h. SEM results showed spherical shaped vesicles. The ability of the prepared atomoxetine HCl loaded fatty acid vesicles to deliver atomoxetine HCl through the nasal route was studied by ex-vivo studies using goat nasal mucosa, which showed sustained release of 51% of the drug up to 4 h.
K. G. Devi and P. K. Lakshmi *
Department of Pharmaceutics, G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad, Telangana, India.
22 February 2020
25 November 2020
30 November 2020
01 February 2021