BURN HEALING POTENTIAL OF NIGELLA SATIVA SEED OIL IN RATSAbstract
Nigella sativa L. (Black cumin) has showed a broad spectrum of pharmacological effects like antipyretic, analgesic, anti-inflammatory and antimicrobial. These activities may be related to the seeds oil. The most important chemical composition of hexanic extract of seeds was unsaturated fatty acids and essential oil. In this investigation the hexanic extract of seeds was topically applied to evaluate the healing efficiency of seeds oil on the second degree burn wound models in rats. Animal were randomly divided into three groups of six for each group. Silver sulfadiazine was applied as an antiseptic standard drug. Wound healing was assessed by the rate of contraction and histological characteristics in treated and untreated groups. On day 12, the extract-treated animals showed 81.20% reduction in the wound area and were significantly (P<0.05) more than control group 63.31%. Histological study showed fully grown regenerated epidermis on day 12 in treated rats. The present study suggests the burn wound healing action of seeds may be due to anti-inflammatory, antioxidant and antimicrobial activities of major compounds oil.
Parisa Sarkhail*, Hadi Esmaily, Amir Baghaei, Abbas Shafiee, Mohammad Abdollahi, Yassaman Khademi, Mahdi Madandar and Pantea Sarkheil
Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, 16th Azar St. Tehran, Iran
06 August, 2010
21 November, 2010
26 December, 2010