CANCER NANOTHERAPEUTICS – A REVIEWAbstract
Present study explains the cancer nano-therapeutics which is rapidly progressing and are being implemented to solve several limitations of conventional drug delivery systems such as nonspecific biodistribution and targeting, lack of water solubility, poor oral bioavailability. To improve the bio-distribution of cancer drugs, nanoparticles have been designed with optimal size and surface characteristics to increase their circulation time in the bloodstream. They are also able to carry their loaded active drugs to cancer cells by selectively using the unique pathophysiology of tumors, such as their enhanced permeability and retention effect and the tumor microenvironment. In this review, we will address, first, the types and characteristics of nanoparticles; second, how nanoparticles are being used as drug delivery systems to kill cancer cells more effectively and also to reduce or overcome drug resistance; and third, how nanoparticles had been formulated and evaluated to improve their therapeutic action, efficacy, and functionality in future cancer treatments. Finally, nanoparticles have greater therapeutic action towards cancer treatment.
A. Rama, M. Anjaneyulu and P. Munija *
Department of Pharmaceutics, Vision College of Pharmaceutical Sciences and Research, Boduppal, Hyderabad, Telangana, India.
31 August 2018
24 November 2018
19 February 2019
01 May 2019