CARDIAC REMODELING: A HARMFUL OR PROTECTIVE MECHANISM OF MYOCARDIUMAbstract
Cardiac remodeling is a progressive morphological change of the myocardium in response to various pathophysiological overloads. Cardiac remodeling occurs due to various mechanisms associated with GPCR and growth receptors. Fundamentally cardiac remodeling is an adaptive mechanism of the myocardium against various overloads. However, depending upon the frequency, strength, and type of overload, these mechanisms can be physiological or pathological. Physiological cardiac remodeling results from controlled overloads that aggravate myocyte hypertrophy and angiogenesis. Pathological remodeling occurs because of excessive overload-induced mechanisms responsible for the over-activation of the immune system and cardiac fibrosis. This review covers the harmful and protective effects of cardiac remodeling and several anti-hypertrophic mechanisms co-occurring. Reviewed literature designates cardiac remodeling as a protective mechanism of myocardium against cardiac overload. However, the overactivation of several inflammatory and other related mediators during cardiac remodeling is liable for its harmful aspects.
Sunny Dhiman *, Inder Kumar, Priyankul Palia and Pankaj Kumar
School of Pharmacy Abhilashi University Mandi, Himachal Pradesh, India.
08 November 2021
01 January 2022
27 January 2022
01 August 2022