CARDIOPROTECTIVE EFFECT OF TERMINALIA ARJUNA ON CAFFEINE INDUCED CORONARY HEART DISEASEAbstract
The present study was aimed to investigate the effects of bark extract of Terminalia arjuna (6.75mg/kg of body weight) on caffeine (10 mg/kg body weight) induced coronary heart disease. Male wistar rats weighing about 120 and 160g were used as the experimental animal for the study. Caffeine dissolved in physiological saline (Nacl) with a pH of 7.0 administered orally to wistar rats continuosly for about 14 days. Thereafter, all the animals at the end of experiment showed a significant elevation in level of total cholesterol, LDL cholesterol, VLDL cholesterol and triglycerides and also a decreased level of HDL-cholesterol, (P< 0.01). When compared to the control rats, co-treatment of rats with caffeine and Terminalia arjuna resulted in an increase in HDL-cholesterol, decrease in serum total cholesterol, triglycerides, LDL cholesterol and VLDL cholesterol as compared to caffeine treated animals with a significant of p<0.05. These findings suggest that the bark extract of Terminalia arjuna has protective effects against caffeine induced coronary heart disease and may have potential as a cardioprotective agent.
S. Asha* and G. Taju
Assistant Professor, Department of Biochemistry, D.K.M., College for Women, (Autonomous), Vellore-632001, Tamil Nadu, India
11 August, 2011
15 September, 2011
15 November, 2011