CERIUM OXIDE NANOPARTICLES APPLICATIONS IN THE FIELD OF CARDIOVASCULAR DISEASESAbstract
Cardiovascular disease (CVD) is the sixth most common human disease that causes about 17.3 million deaths yearly. Advancement in nanomedicine enables the usage of nanomaterials for treating cardiac disorders. Among these, Cerium Oxide (CeO2) nanoparticle is gaining attention due to their irreversible oxidative states (Ce3+ and Ce4+), which provide them with many unique, physiologically important traits like antioxidant property, Anti-inflammatory property, free radicle scavenging potential etc. All these features make CeO2 an excellent agent for treating many cardiac related disorders. We have used the search engines PubMed and Google scholar to identify the relevant papers in last 5 years on this topic. Some old classical articles were also identified, and the review was written based on these relevant papers. Cerium nanoparticles (CeNPs) are being used in the therapy of CVD mainly for reducing oxidative stress, inflammation, and damage caused by free radicals. CeO2 can also protect endothelial cells (ECs) from apoptosis. It can be used as a wound-healing agent during cardiac surgeries. This is because of its potential to enhance endothelialization. In this article, we reviewed various applications of CeO2 in the field of CVD.
M. K. Shurfa, Agnishwar Girigoswami and Koyeli Girigoswami *
Medical Bionanotechnology, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Chettinad Health City, Rajiv Gandhi Salai, Kelambakkam, Tamil Nadu, India.
16 May 2022
02 August 2022
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01 February 2023