CHALCONE – PROMISING ENTITY FOR ANTICANCER ACTIVITY: AN OVERVIEW
AbstractChalcones are naturally occurring compounds with a wide range of biological activities along with an anticancer activity through various mechanisms. It is also known as aromatic ketone, which creates a central core for different essential biologically active compounds. The literature on anticancer chalcones shows the use of various prolonged approaches like structural manipulation and replacement of both aryl rings, molecular hybridization by combination with other pharmacological important moieties to enhance anticancer characteristics. Methoxy substitution on both the chalcones A and B aryl rings based on their position in the aryl rings, usually affect anticancer and other activities. Additionally, chalcones affect the anticancer activity proven through the various categories of compounds. Hybrid chalcones developed by chemically linking chalcones to other leading anticancer scaffolds such as benzodiazepines, imidazole, benzothiazole have proved complementary or intrinsic pharmacological behavior. This study summarizes the concerted attempts made in the design and growth of anticancer chalcones reported in the latest literature and also gives an overview of recently released patents.
Article Information
7
2027-2041
577
1178
English
IJPSR
A. A. Alman *, K. Daniel and S. G. Killedar
Department of Pharmacy, B. R. Nahata College of Pharmacy, Mandsaur University, Mandsaur, Madhya Pradesh, India.
nandanvan0088@gmail.com
12 July 2019
23 November 2019
03 April 2020
10.13040/IJPSR.0975-8232.11(5).2027-41
01 May 2020
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