CHARACTERIZATION AND QUANTIFICATION OF ETHYLHEXYLGLYCERINAbstract
Ethylhexylglycerin is an alkyl glyceryl ether. This means that the ethyl hexyl group is bound to glycerin at one end by an ether linkage. it has been used as a common ingredient in bath products, body and hand products, cleansing products, deodorants, eye makeup, foundations, hair care products and suntan products. The compound is synthesized by esterfication of 2-Ethylhexanol and epichlorohydrin, followed by ring opening reaction of epoxy positioned at 1st and 2nd carbon in the chemical structure. It was characterized by NMR, seven -CH2 (position 10, 11, 9, 8, 6, 4 and 2) carbons present at negative side. Tertiary carbons are present at chemical shifts 39 ppm and 70 ppm (position at 7 and 3) and primary carbons are present at chemical shifts 10 ppm and 13 ppm (position at 14 and 12). Both primary and tertiary carbons were found on the positive side of the spectrum. From FTIR studies, peak corresponding to -OH stretch is observed at 3,391 cm-1 and the -OH bending is seen at 1,111 cm-1. By Mass characterization, the m/z value of the sample was found to be 204.9 (ES–) which represents Ethylhexylglycerin. The purity and impurity profile of material was achieved by GC-FID method with >99.0%.
R. Arla *, J. S. Rao and K. Koumaravelou
Department of Pharmacy, Prist University, Thanjavur, Tamil Nadu, India.
05 November, 2017
26 January, 2018
06 February, 2018
01 April, 2018